Glycyrrhiza glabra is commonly known as Licorice/Liquorice, Sweet wood, Mulahatti and Yashtimadhu, Jeshthamadh. Glycyrrhiza glabra is a widely used classical medicinal plant and is found in numerous traditional formulas. The root of G.glabra relieves thirst, cough, asthma, bronchitis, abdominal colic, eye troubles and cures ulcers. It has various medicinal properties like wound healing activity, antiulcer activity, memory enhancing activity, hair growth promoting activity, antithrombotic effect, hepatoprotective effect, cerebroprotective effect, antidyslipidaemic activity, antioxidant activity etc.Licorice has been recommended as a prophylactic agent for gastric and duodenal ulcers. It is employed in dyspepsia as an anti-inflammatory agent during allergenic reactions . It is used as a contraceptive, laxative, anti-asthmatic, emmenagogue, galactagogue, anti viral agent. It is also effective against anemia, gout, sore throat, tonsillitis, flatulence, sexual debility, hyperdypsia, fever, skin diseases, swellings. Licorice is effectively used in acidity, leucorrhoea, bleeding, jaundice, hiccough, hoarseness, bronchitis, vitiated conditions of Vata dosha, gastralgia, diarrhea, fever with delirium and anuria
Licorice is a Herb of 1 to 1.5 meter in height. It grows in the sub - tropical and warm temperate regions of the world. Licorice grows in fertile, sandy or clay soil near a river or stream where enough water is available for the plant to flourish in the wild, or under cultivation where it can be irrigated. It is native to Arabia, Persian, Gulf, Afganisthan, Turkesthan, Asia minor, Siberia etc but the root is cultivated in the Punjab, Sub Himalayan tracts from the Chenab eastwards, Sindh & Peshwar Valley, Burma & Andaman Islands in India and Pakistan. Dried licorice roots are found in all the bazaars of India.
The roots of Glycyrrhiza glabra Linn.contain glycyrrhizin, which is a saponin that is 60 times sweeter than cane sugar; Flavonoid rich fractions include liquirtin, isoliquertin liquiritigenin and rhamnoliquirilin and five new flavonoids- glucoliquiritin apioside, prenyllicoflavone A, shinflavanone, shinpterocarpin and 1-metho-xyphaseolin licopyranocoumarin, licoarylcoumarin, glisoflavone and new coumarin-GU-12. Four new isoprenoid-substituted phenolic constituents – semilicoisoflavone B, 1-methoxyficifolinol, isoangustone A, and licoriphenone isolated from roots. . Root contains 3.6% glycyrrhizin, a yellow amorphous powder-asparagine, a glycoside isoliquirtin 2.2%, glucose 3.8%, starch, gum, mucilage, amorphous, sulphuric acid and metallic acids, calcium and magnesium salts.
PROPERTIES AND USES:
SIDE EFFECTS OF EXCESS CONSUMPTION:
- High Blood Pressure
- Low Potassium Levels
- Occasionally Brain Damage
- Absence Of A Menstrual Period In Women
- Water And Sodium Retention
As mentioned in Ayurvedic Pharmacology, 1gm to 2 gm of Root powder is safe for consumption
1.One of the very common side effects of Radiation/Chemotherapy especially of the head and neck malignancies is mucositis. Mucositis decreases immunity and quality of life as well as poor tolerance to surgery and altered efficacy of Chemotherapy and Radiotherapy. This study was designed with an objective to minimize the radiation induced mucositis, skin reaction, xerostomia, change in voice etc. with an Ayurvedic preparation YashtimadhuGhrita (processed ghee). Total 75 patients were randomly divided into four groups and drugs were administered: Group A with local application of Yashtimadhu powder and honey in the oral cavity for few minutes prior to radiotherapy along with oral intake of Yashtimadhu Ghrita; Group B with only local application of the Yashtimadhu powder and honey in the oral cavity; Group C patients administered with only local application of honey in the oral cavity; Group D on conventional modern medication controlled group. All these patients under four groups received Radiotherapy and Chemotherapy for maximum duration of 7 weeks. Mucositis and Skin reactions were observed in 100% of patients with varying degree. The intensity of Radiation and Chemotherapy induced mucositis was reduced to a great extent by the trial drug. Hence, Yashtimadhu (Glycyrrhiza glabra) can be used effectively in prevention and treatment of oral mucositis post radiation and chemotheraphy in patients of cancer, especially of the head and neck region.
2. The postmenopausal period associated with significant increase in the incidence of age makes a woman prone to more diseases. In Ayurveda, menopause is a result of jaravastha caused due to change in time, mostly degenerative in which, Vata dosha is predominant along with depletion of all the seven dhatus. This study made an effort to study the impact of Yashtimadhu (Glycyrrhiza glabra Linn.) in menopausal syndrome. The patients suffering from Postmenopausal syndrome were divided into two groups, Group A milk as Anupana and Group B water as Anupana for Yastimadhu. Each group contained 15 patients. All the patients were advised to take 3 grams powdered Yastimadhu roots in three divided doses for a period of 45 days. The result showed that the Yastimadhu root powder showed more significance in patients confined to milk as Anupana due to its Rasayana effect than patients in water as Anupana.
3. The following study was undertaken with an aim to evaluate the effect of Yashtimadhu (Glycyrrhiza Glabra ) oral supplementation on the mental intelligence and memory function of the male students. For this purpose tablets were formulated from the crude powder prepared from roots were subjected to dose standardization process. 1 tablet BID (two times in a day) was found to be suitable without any side effects. With this dose the final study was conducted in 123 male students. Students were divided into two group, treatment (1 tablet BID) and placebo control (received starch powder) for the period of 60 days. Each group was further subdivided into two, low and high intelligence percentage. Evaluation of improvement among these students was judge by using parameters such as NVIT (Non Verbal Intelligence Test) and memory test score before the start of treatment and end of treatment period and scored them accordingly into poor, moderate, good and, very good and expressed in percentage. The overall NVIT results indicated that oral consumption of Yashtimadhu tablets BID improves the intelligence level among the student when compared to students who received placebo treatment. In both classes mild memory improvement with Yashtimadhu treatment was observed as compared to control students. The improvement was observed in NVIT as compared to memory was quite higher. Thus this study concludes that Yashtimadhu has a potential to improve the general intelligence
PRECAUTION AND WARNING:
Pregnancy and breast-feeding: It is unsafe to take licorice during pregnancy. High consumption of licorice during pregnancy, about 250 grams of licorice per week, seems to increase the risk of early delivery. It might cause a miscarriage or early delivery.
Heart disease: Licorice can cause the body to store water, and this can make congestive heart failure worse. Licorice can also increase the risk of irregular heartbeat.
High blood pressure: Licorice can raise blood pressure. Avoid Licorice in case of high blood pressure.
Hypertonia: Licorice can cause the level of potassium to drop in the blood. This can make hypertonia worse.
Hypokalemia: Licorice can lower potassium in the blood. If your potassium is already low, licorice might make it too low.
Sexual problems in men: Licorice can lower a man's interest in sex and also worsen erectile dysfunction (ED) by lowering levels of testosterone.
Surgery: Licorice might interfere with blood pressure control during and after surgery. One must stop taking licorice at least 2 weeks before a scheduled surgery.
INTERACTION WITH MEDICATION:
- Warfarin (Coumadin) interacts with LICORICE
Warfarin (Coumadin) is used to slow blood clotting. The body breaks down warfarin (Coumadin) to get rid of it. Licorice might increase the breakdown and decrease the effectiveness of warfarin (Coumadin). Decreasing the effectiveness of warfarin (Coumadin) might increase the risk of clotting.. The dose of warfarin (Coumadin) might need to be changed.
- Digoxin (Lanoxin) interacts with LICORICE
Large amounts of licorice can decrease potassium levels in the body. Low potassium levels can increase the side effects of digoxin (Lanoxin).
- Estrogens interacts with LICORICE
Licorice seems to change hormone levels in the body. Taking licorice along with estrogen pills might decrease the effects of estrogen pills. Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
- Ethacrynic Acid (Edecrin) interacts with LICORICE
Licorice can cause the body to get rid of potassium. Ethacrynic acid (Edecrin) can also cause the body to get rid of potassium. Taking licorice and ethacrynic acid (Edecrin) together might cause potassium to become too low.
- Furosemide (Lasix) interacts with LICORICE
Licorice can cause the body to get rid of potassium. Furosemide (Lasix) can also cause the body to get rid of potassium. Taking licorice and furosemide together might cause the potassium levels in your body to go too low.
- Medications changed by the liver (Cytochrome P450 2B6 (CYP2B6) substrates) interacts with LICORICE
Some medications are changed and broken down by the liver.Licorice might decrease how quickly the liver breaks down some medications. Taking licorice along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Some of these medications changed by the liver include ketamine (Ketalar), phenobarbital, orphenadrine (Norflex), secobarbital (Seconal), dexamethasone (Decadron), and others.
- Medications for high blood pressure (Antihypertensive drugs) interacts with LICORICE
Large amounts of licorice seem to increase blood pressure. By increasing blood pressure licorice might decrease the effectiveness of medications for high blood pressure. Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), amlodipine (Norvasc), hydrochlorothiazide (HydroDIURIL), furosemide (Lasix), and many others.
- Medications for inflammation (Corticosteroids) interacts with LICORICE
Some medications for inflammation can decrease potassium in the body. Licorice might also decrease potassium in the body. Taking licorice along with some medications for inflammation might decrease potassium in the body too much. Some medications for inflammation include dexamethasone (Decadron), hydrocortisone (Cortef), methylprednisolone (Medrol), prednisone (Deltasone), and others.
- Water pills (Diuretic drugs) interacts with LICORICE
Large amounts of licorice can decrease potassium levels in the body. Water pills can also decrease potassium in the body. Taking licorice along with water pills might decrease potassium in the body too much. Some water pills that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDIURIL, Microzide), and others
All Nisarga Herbs products are tested and have no side effects.
Yashtimadhu Root Ghan (Glycyrrhiza Glabra) - 220mg , Excipient - q.s.
Yashtimadhu Root Ghan (Glycyrrhiza Glabra) - 220mg
Yashtimadhu is an effective anti-inflammatory herb. It helps to harmonize the body and provide necessary isoflavones.